Speaker: Dr. April M. Kloxin, University of Delaware
Moderator: Dr. Dianne Poster, National Institute of Standards and Technology (NIST)
February 13, 2024, 2:00 PM – 3:00 PM EST

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https://us02web.zoom.us/webinar/register/WN_8uzy37okTc6A74HunqEjgg

Webinar Overview:
Photopolymerizations provide great opportunities for the creation of controlled, bioinspired microenvironments for probing and directing complex biological systems. For example, photopolymerizations can be utilized to create reductionist synthetic extracellular matrices (ECMs) with tunable biophysical and biochemical properties for asking questions about the role of different microenvironment cues in tissue regeneration and disease processes or for promoting desired cellular functions for therapeutic applications. In this arena, we recently have designed well-defined photopolymerized hydrogels inspired by common sites in the human body (e.g., bone marrow, lungs) for the late recurrence of breast cancer. We have applied these photopolymerized 3D cultures, along with a range of molecular tools, to dissect different cell-matrix and cell-cell interactions in breast cancer dormancy and re-activation and evaluate therapeutic strategies for preventing late recurrence. Additionally, for enhancing the production of cell therapies, we collaboratively have established a modular manufacturing platform that combines photopolymerized hydrogel coatings with commercial flow-based membrane devices for improved activation, expansion, and transduction of human T-cells. Together, our results demonstrate the great utility of photopolymerizations for the creation of soft biomaterials with precisely controlled properties for addressing outstanding needs in improving human health.